منابع مشابه
Interaction between clopidogrel and proton pump inhibitors.
The drug interaction between proton pump inhibitors and clopidogrel has been the subject of much study in recent years. Contradictory results regarding the effect of proton pump inhibitors on platelet reactivity and on clinical outcome in clopidogrel-treated patients have been reported in literature. Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopi...
متن کاملProton pump inhibitors, genetic polymorphisms and response to clopidogrel therapy.
Clopidogrel has become part of the mainstay of therapy for acute coronary syndromes and in patients post stenting. Clopidogrel is a pro drug and is metabolised by liver enzymes, particularly CYP2C19, into its active form. A considerable proportion of patients have a poor response to clopidogrel and this may be due to several factors. Genetic polymorphisms involved in clopidogrel's absorption, m...
متن کامل[Clinical significance of interactions between clopidogrel and proton pump inhibitors].
1Katedra i Zakład Promocji Zdrowia, Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera, Bydgoszcz 2Katedra i Klinika Kardiologii i Chorób Wewnętrznych, Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera, Bydgoszcz 3Katedra i Zakład Farmakologii i Terapii, Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygie...
متن کاملDrug interaction between clopidogrel and proton pump inhibitors.
Proton pump inhibitors (PPIs) have been recommended for reducing the risk of gastrointestinal bleeding associated with dual antiplatelet therapy (aspirin plus clopidogrel). However, studies have found decreased efficacy of clopidogrel when concurrently administered with a PPI. To determine the mechanism of and evidence for the potential interaction between clopidogrel and PPIs, along with the c...
متن کاملClopidogrel and proton pump inhibitors: a new drug interaction?
Clopidogrel is a thienopyridine platelet antagonist that irreversibly inhibits the binding of adenosine diphosphate to platelet receptors, ultimately leading to inhibition of platelet aggregation. Clopidogel is a prodrug requiring hepatic bioactivation via cytochrome P450 isozymes (CYP2C19, CYP3A4, CYP3A5) to its pharmacologically active form. Inhibition of cytochrome P450 may interfere with me...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2014
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.114-0014